In a new study published in Lupus Science & Medicine, researchers found a connection between renal (kidney) response and long-term renal outcomes. People with lupus nephritis (LN, lupus-related kidney disease) who achieved modified primary efficacy renal response (mPERR) or modified complete renal response (mCRR) were associated with improved long-term renal survival.
In this retrospective, observational study, the records of 179 people with systemic lupus erythematosus (SLE) and biopsy-proven LN were analyzed and indexed as responders or non-responders based on mPERR or mCRR criteria, including estimated glomerular filtration rate (eGFR, measure of how well the kidneys are removing waste from the blood) and proteinuria, at 24 months post-biopsy. Researchers found that long-term survival was achieved in 78.9% of mPERR responders and 60.8% of non-mPERR responders. Achieving mPERR increased the likelihood of long-term renal survival. A similar connection was discovered with mCRR, wherein 80.4% of mCRR responders and 64.9% of non-mCRR responders achieved long-term survival.
The findings support use of mPERR and mCRR as predictive measures for long-term renal survival. Incorporating these measures into regular clinical practice could facilitate earlier treatment interventions, potentially preventing irreversible kidney damage and end-stage kidney disease in people with LN. More research is needed to evaluate earlier timepoints for attaining mPERR and mCRR to identify the best timing for assessing remission. Learn more about lupus and the kidneys.
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