A complex and mysterious disease, the causes of systemic lupus erythematosus (SLE) remain unknown. In a new study, researchers discovered a mechanism that may contribute to lupus development and a possible new approach to reverse or cure the disease.
Scientists examined the blood of 19 people with SLE and compared it to those of healthy individuals.
They found that Type I interferon modulates a receptor called aryl hydrocarbon receptor (AHR) which leads to increased production of a subset of T cells that activate B cells, resulting in an increase in inflammation.
Identifying what causes lupus is paramount to finding a cure and to discovering better treatment approaches for people living with the disease. These findings in a small number of people living with lupus are promising but will need to be validated in larger populations.
This study was co-authored by Karen Costenbader, MD, MPH, Medical Scientific Advisory Council Chair for the Lupus Foundation of America. Learn more about understanding lupus.
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