Lupus Foundation of America Greater Ohio Chapter Logo

Toll Free: 1 (888) NO-LUPUS
Phone: (440) 717-0183

Help Us Solve The Cruel MysteryTM

Donate To The Ohio Chapter

FDA Approves a Phase 1 Trial for Investigational Therapy, CB-010, for Lupus Nephritis Treatment

by | Apr 19, 2024

Inside Lupus Research (ILR): Treatment News

The U.S. Food & Drug Administration has granted approval for a Phase 1 study to evaluate the safety and efficacy of investigational therapy, CB-010, for treatment of lupus nephritis (LN). The GALLOP study will begin by year-end and will also be evaluated for people with extrarenal lupus (when LN symptoms affect other parts of the body). 

CB-010 is a CAR-T cell therapy. CAR-T cell therapy targets B cells, which are immune system cells involved in the production of autoantibodies and lupus disease activity. To make CAR-T cells, scientists create or engineer new cells called chimeric antigen receptors (CARs), and then introduce T-cells into them. CB-010 targets CD19, a protein found on the surface of B cells, and produces autoantibodies and uses a person’s own immune T-cells. Additionally, researchers have engineered CB-010 cells to lack the PD-1 protein to bolster CAR-T cell performance. 

The therapy has already shown encouraging results in people with relapsed or refractory B-cell non-Hodgkin lymphoma. Continue to follow the Lupus Foundation of America for updates on lupus drug developments and clinical trials. Learn more about treatments being studied for lupus.

Read the announcement

This post was originally published on this site

Skip to content