A new literature review explores the emerging application of CAR-T cell therapy in treating people with Systemic Lupus Erythematosus (SLE). Preliminary data suggests that CAR-T therapy may significantly improve both serologic and clinical outcomes in people with SLE, offering encouragement for a possible cure in the future.
In early reports, CAR-T therapy has led to clinical remission and allowed patients to discontinue immunosuppressive medications, maintaining disease control without ongoing drug therapy. However, these results have only been observed in a small number of young patients with severe, treatment-resistant lupus.
In their review, the authors identify the following essential steps to deepen knowledge and application of CAR-T therapy:
- Comprehensive research to confirm early findings and clinical trials to evaluate both the immediate and long-term effectiveness and safety in various patient groups.
- Determination of suitable patient populations, as CAR-T therapy could also mitigate compliance challenges.
- Cost considerations. Although currently expensive, the cost is comparable to the long-term expenses associated with severe SLE treatment. Efforts to lower costs, such as improving production efficiencies and exploring outpatient treatment options, need continued investigation.
- Early intervention could improve CAR-T therapy practicality and significantly impact long-term outcomes.
Although it’s significantly more expensive than other treatments, it has the potential to make the word “cure” become a little more realistic. Further research and controlled studies are needed to ensure the efficacy and safety of CAR-T in all diverse populations and reduce financial barriers.
CAR-T therapy marks a significant step forward in SLE treatment, highlighting the need for immediate and concentrated research and clinical implementation. Study author, David Isenberg, is a past recipient of the Lupus Foundation of America Evelyn Hess Award. Learn more about CAR-T cell therapy for treating lupus.
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