A new study found a high prevalence of chronic kidney disease (CKD) among people with systemic lupus erythematosus (SLE), including in people without a diagnosis of lupus nephritis (LN, lupus-related kidney disease). In addition, individuals with both lupus and CKD experienced significantly higher rates of hospitalization and mortality compared to those without CKD.
This study reviewed medical records from 175 adults living with SLE. CKD was identified using a combination of estimated glomerular filtration rate (eGFR) and albuminuria (protein in the urine), two key biomarkers of early kidney damage. Statistical analysis revealed that 54.6% of participants met the criteria for CKD. While CKD was more common among those with a history of LN, this association was not statistically significant, 46.1% of people with CKD had no history of LN. CKD was associated with higher rates of all-cause hospitalization and mortality.
These findings underscore the importance of proactive monitoring in people with SLE. Testing for both eGFR and albuminuria in all people with lupus—not just those diagnosed with LN—may lead to earlier detection of CKD. Early detection may allow for interventions that could slow progression and improve outcomes, , including morbidity and mortality associated with CKD in people with SLE. Learn more about lupus and the kidneys.
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